相关实验视频

Updated: Jun 29, 2025

Murine Colitis Modeling using Dextran Sulfate Sodium DSS
08:39

Murine Colitis Modeling using Dextran Sulfate Sodium DSS

Published on: January 19, 2010

49.9K

针对TSLP的抗体抑制了DSS诱导的大肠炎和JAK2/STAT5通路在小鼠中的激活

Wei Zhuang, Zhen Li

    European cytokine network
    |March 25, 2024
    PubMed
    概括

    使用tezepelumab向胸膜流体淋巴蛋白 (TSLP) 可能可以治疗炎症性肠病 (IBD). 这项研究在IBD小鼠中发现TSLP和JAK2 / STAT5通路的激活,该治疗tezepelumab逆转,减少炎症和屏障损伤.

    关键词:
    通过JAK2/STAT5路径.这是一种炎症炎症炎症炎症.炎症性肠病是一种炎症性肠病.粘膜屏障是一种阻碍.胸膜流体的淋巴发育蛋白.

    更多相关视频

    Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma10:21

    Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

    Published on: September 20, 2024

    427
    Investigating Intestinal Inflammation in DSS-induced Model of IBD08:43

    Investigating Intestinal Inflammation in DSS-induced Model of IBD

    Published on: February 1, 2012

    67.2K

    相关概念视频

    The JAK-STAT Signaling Pathway01:20

    The JAK-STAT Signaling Pathway

    Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
    8.9K