在大气氧化后出现孤儿基酶蛋白的出现
Bruno Cuevas-Zuviría1, Amanda K Garcia1, Alex J Rivier1
1Department of Bacteriology, University of Wisconsin-Madison, Madison, WI, USA.
Molecular biology and evolution
|March 25, 2024
概括
对于固化必不可少的G子单元蛋白质,在化后超过10亿年出现. 它的进化使微生物能够利用新的金属,扩大它们的生态作用.
科学领域:
- 生物地质化学生物地质化学
- 分子进化分子进化
- 微生物生态学 微生物生态学
背景情况:
- 生物固定对于元素循环至关重要.
- 早期酶的分子起源,如基酶,仍然在很大程度上是未知的.
- G亚单元是一种与酶功能相关的古老蛋白质.
研究的目的:
- 研究基酶G子单元蛋白的起源和演变.
- 了解G子单元在酶金属依赖和微生物适应中的作用.
- 探索进化新如何塑造微生物创新.
主要方法:
- 基酶G子单元演变的遗传学分析.
- 祖先蛋白质的实验室重建实验.
- 生物信息识别与金属依赖相关的分子特征.
主要成果:
- G子单元产生了新的金属依赖性,与25亿年前的环境变化有关.
- 分子特征表明G子单元介导的辅因子/蛋白质相互作用用于新的金属利用.
- 在G子单元进化中的功能专业化取决于先前存在的分子特征.
结论:
- G子单元的出现促进了微生物适应不断变化的地化学环境.
- 进化历史和偶然的新奇是重要的微生物创新的关键驱动力.
- 了解早期的酶进化提供了对全球生物地球化学循环的洞察力.
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