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相关概念视频

Cell Specific Gene Expression01:58

Cell Specific Gene Expression

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Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
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Apoptosis01:30

Apoptosis

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Apoptosis is a combination of two Greek words, 'apo' and 'ptosis,' meaning separation and falling off, respectively. Hippocrates used this word to describe gangrene, which was caused due to bandaging of fractured bones. Apoptosis was distinguished from necrosis in 1970 when John Kerr reported observations of morphological changes occurring during apoptosis. During one experiment, he observed that the disruption of blood supply to the liver tissue resulted in a size...
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Aquaporins01:25

Aquaporins

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Aquaporins or AQPs are a family of integral membrane proteins whose primary function is to transport water, while some called aquaglyceroporins also transport glycerol. In addition, aquaporins have also been suspected to be involved in transporting volatile substances, such as carbon dioxide and ammonia, across membranes. Such AQPs that act as gas channels are often highly expressed in cells involved in the gaseous exchange, such as red blood cells, epithelial cells, and pulmonary capillaries.
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Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal01:22

Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal

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Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
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General Transcription Factors01:30

General Transcription Factors

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Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
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Maintenance of the ES Cell State01:14

Maintenance of the ES Cell State

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The cells of the blastocyst inner cell mass only remain pluripotent for a short time. This state of pluripotency and self-renewal can be maintained in embryonic stem (ES) cell culture by adding specific chemicals or growth factors to ensure the cells can continue dividing and later differentiate into different cell types. In some cases, the cells are grown on a feeder layer of differentiated cells, which provides the growth factors and extracellular matrix components necessary for stem cell...
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相关实验视频

Updated: Jun 29, 2025

Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis
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Mechanism of Regulation of Adipocyte Numbers in Adult Organisms Through Differentiation and Apoptosis Homeostasis

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异形和细胞状态特定的APOE稳态和功能.

Karina Lindner1,2, Anne-Claude Gavin1,2

  • 1Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland.

Neural regeneration research
|March 25, 2024
PubMed
概括

脂蛋白E (ApoE) 对于大脑脂质运输和神经元存活至关重要. 其改变的平衡与阿尔茨海默病风险有关,突出显示了ApoEE.

科学领域:

  • 神经科学是一个神经科学.
  • 生物化学 生化学
  • 遗传学 是一个遗传学.

背景情况:

  • 脂蛋白E (ApoE) 是大脑中主要的脂质运输体.
  • ApoE支持神经元存活和神经元-星细胞代谢合.
  • ApoE遗传变异会影响阿尔茨海默病的风险.

研究的目的:

  • 审查阿尔茨海默氏病对阿波利波蛋白E恒温的影响.
  • 探索AD中ApoE合成,分泌,降解和脂化中的变化.
  • 了解ApoE在神经退行过程中的作用.

主要方法:

  • 关于ApoE和阿尔茨海默病现有研究的文献综述.
  • 对大脑中ApoE代谢的研究分析.
  • 综合当前关于AD的ApoE稳态的知识.

主要成果:

  • 在阿尔茨海默病中,Apolipoprotein E的平衡被显著破坏.
  • 阿尔茨海默病影响了ApoE代谢的关键过程,包括合成,分泌,降解和脂化.
  • 这些干扰有助于疾病的发病和风险.

结论:

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  • 阿波利波蛋白E稳态是阿尔茨海默病的一个关键因素.
  • 了解ApoE代谢变化是开发治疗策略的关键.
  • 对ApoE在神经退行症中的作用进行进一步的研究是有必要的.