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改变的微生物肠肺轴在人类耐火性慢性咳的发病过程中的首次探索
Simone Baldi1, Alessio Fabbrizzi2, Leandro Di Gloria3
1Department of Experimental and Clinical Medicine, University of Florence, Largo Brambilla 3, 50134, Florence, Italy.
Lung
|March 25, 2024
概括
耐药性慢性咳 (RCC) 与肠道和口腔微生物群的显著变化有关. 这些肠肺沟通的变化可能为治疗持续咳提供新的治疗点.
科学领域:
- 微生物组研究的研究.
- 肠肺轴 肠肺轴 肠肺轴
- 呼吸系统药物 呼吸系统药物
背景情况:
- 咳是一种自然的防御机制,但如果持续,可能会变得有害.
- 耐火性慢性咳 (RCC) 影响大约20%的人.
- 了解肠肺轴对于探索新的治疗策略至关重要.
研究的目的:
- 研究RCC患者肠道微生物群 (GM) 和口腔微生物群 (OM) 的变化.
- 描述RCC患者肠道和口腔微生物组的组成和功能变化.
- 探索肠肺沟通在耐火性慢性咳病变中的作用.
主要方法:
- 使用16S rRNA测序分析了RCC患者和健康对照组 (HC) 中的GM和OM组成.
- PICRUST2被用于微生物群落的功能概况.
- 气相色谱被用来测量便短链脂肪酸水平和无血清脂肪酸 (FFA) 丰度.
主要成果:
- 与HC相比,RCC患者在GM和OM中表现出增加的唾液α多样性和显著的β多样性.
- 在RCC患者的便和唾液样本中观察到Firmicutes/Bacteroidota比率的显著变化.
- 功能分析表明,脂聚糖生物合成和脂酸代谢途径在便中可能过度表达,以及RCC患者的血清FFA水平发生变化.
结论:
- 在RCC患者中发现了肠道和口腔微生物群组成和功能的显著差异.
- 这些发现凸显了肠肺沟通改变在RCC病变发生过程中的潜在作用.
- 这项研究表明,恢复ebiotic肠肺通信可能会导致RCC管理的新营养或药理干预措施.
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