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与COVID-19相关的继发性硬化胆管炎与肝移植

Anne Kristin Fischer¹, Dirk Stippel², Ali Canbay³

¹Institute of Pathology, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany. Anne.Kristin.Fischer@uk-koeln.de.

Virchows Archiv : an international journal of pathology

|March 25, 2024

概括

在SARS-CoV-2感染和长期机械通风后,两名重症监护病患患上了严重的二次硬化胆管炎 (SSC),需要进行肝移植. 这突显了严重的COVID-19影响胆道系统的关键并发症.

科学领域:

肝病学肝病学是一种肝病学.
病毒学病毒学
关键护理医学关键护理医学

背景情况:

严重的COVID-19可能导致长时间的重症监护,包括人工呼吸和ECMO.
二次性硬化胆道炎 (SSC) 是一种严重的胆道疾病,可能发生在危急病患者中.
在这种情况下,SSC的发病过程涉及复杂的因素,包括缺血和感染.

研究的目的:

报告两例针对SARS-CoV-2相关的SSC的肝移植 (OLTX) 病例.
阐明推动SSC在COVID-19和重症监护后发展的潜在机制.

主要方法:

关于两名接受 орто托普肝移植 (OLTX) 的患者的病例报告.
分析临床过程,疾病进展和潜在的病因因素.
关于SARS-CoV-2,重症监护和胆道疾病的文献审查.

主要成果:

两名SARS-CoV-2患者发展出快速进展的SSC,需要OLTX.
SSC呈现了胆血管病变,胆道损失,胆,纤维化和肝硬化.
病原发生可能涉及周脉输液受损,感染和潜在的直接病毒影响.

结论:

与SARS-CoV-2相关的SSC是在重症患者中出现的严重,渐进的胆道并发症.
多因素的发病因子包括缺血-再输液损伤和潜在的病毒细胞损伤有助于SSC.
对于末期疾病可能需要进行正位体肝移植.

关键词:

在COVID-19感染的过程中,肝脏病理肝脏病理肝脏移植肝脏移植二次性硬化性胆管炎的发生.血管病变是一种血管病.

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