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库尔库涂层:一种新的解决方案,以减轻固有的碳纳米管毒性

Samiksha Rele¹, Chanchal Kiran Thakur², Fatima Khan²

¹Infection Bioengineering Group, Department of Biosciences and Biomedical Engineering, Indian Institute of Technology Indore, Simrol, Indore, MP, 453552, India.

Journal of materials science. Materials in medicine

|March 25, 2024

概括

用黄素涂覆多壁碳纳米管 (MWCNTs) 显著降低了它们的毒性. 这种库尔库明涂层减轻了炎症,氧化应激和细胞死亡,使MWCNT更安全用于药物输送应用.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
毒理学毒理学毒理学

背景情况:

多壁碳纳米管 (MWCNTs) 用于向药物输送,但在高度或长时间暴露时可以诱导细胞毒性,炎症和氧化应激.
黄素,源自长,具有已知的抗炎,抗氧化和细胞保护性质.

研究的目的:

合成和表征黄素涂层的,素功能化的MWCNTs.
评估黄素涂层对MWCNTs的细胞保护性,抗炎性,抗氧化和抗菌作用.

主要方法:

合成和表征黄素涂层,素功能化的MWCNTs.
在转录和蛋白质水平上评估炎症标志物 (IL-6,IL-8,IL-1β,TNFα,NFκB).
测量活性氧物种 (ROS) 生产和抗氧化酶 (catalase) 活性.
评估线粒体膜潜力和细胞死亡.

主要成果:

与未涂层的MWCNT相比,黄素涂层显著减少了炎症分子 (IL-6,IL-8,IL-1β,TNFα,NFκB).
与黄素涂层的MWCNT一起观察到减少ROS产量和升调的catalase活性.
黄素涂层促进了线粒体膜潜力的恢复,并减少了细胞死亡.

结论:

黄素涂层有效地减轻MWCNTs的不良影响,包括炎症,氧化应激和细胞毒性.
这一战略提高了MWCNT在潜在的生物医学应用中的安全性,特别是在药物输送中.

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