轻度残疾多发性硬化症患者自我感知生活质量的决定因素:一个横截面研究
Silvy Pilotto1,2, Matteo Floris3, Paolo Solla4,5
1Department of Medical, Surgical and Experimental Medicine, University of Sassari, Sassari, Italy. pilottosilvy@gmail.com.
Journal of neurology
|March 25, 2024
概括
精神健康因素,如焦虑和精神症状,以及疲劳和年龄,在轻度残疾的多发性硬化症患者中显著影响自我感知与健康相关的生活质量 (spHRQoL).
科学领域:
- 神经学 神经学
- 生活质量研究 研究 生命质量研究
- 精神病体医学是一种精神病体医学.
背景情况:
- 严重残疾多发性硬化症 (pwMS) 患者的自我感知与健康相关的生活质量 (spHRQoL) 已得到充分研究.
- 有限的数据存在影响pwMS中spHRQoL的因素与轻度的身体损伤.
研究的目的:
- 在撒丁岛 pwMS 中确定 spHRQoL 的关键决定因素,其扩展残疾状态量表 (EDSS) 低于 2.5.5.
- 调查心理和身体因素对这个特定人群中的spHRQoL的影响.
主要方法:
- 研究了一组没有严重认知障碍的87名门诊pwMS (EDSS <2.5) 的队列.
- 使用SF-36评估了spHRQoL,以物理组件摘要 (PCS) 和心理组件摘要 (MCS) 为结果.
- 多变量通用线性模型分析了PCS/MCS与包括心理症状,年龄,疲劳和焦虑在内的因素之间的关联.
主要成果:
- 与规范数据相比,心理组件摘要 (MCS) 显著减少,而物理组件摘要 (PCS) 没有显著差异.
- 较低的PCS得分与精神症状,年龄较大和疲劳有关 (p < 0.05).
- 较低的MCS得分与焦虑的存在有显著的关联 (p < 0.001).
结论:
- 情绪,精神症状,疲劳和年龄是影响轻度致残多发性硬化症患者spHRQoL的重要因素.
- 这些因素应纳入轻度残疾pwMS的临床管理策略.
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