与PFAS相关的免疫毒性的公共卫生风险是真实的
Abigail P Bline1,2, Jamie C DeWitt3, Carol F Kwiatkowski4
1Social Science Environmental Health Research Institute, Northeastern University, Boston, MA, 02115, USA. a.bline@northeastern.edu.
和多基物质 (PFAS) 暴露与减少疫苗反应有关. 目前的法规未能充分纳入PFAS免疫毒性数据,危及公众健康. 我们建议使用所有免疫毒性数据来更好地评估风险和临床指导.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 免疫学 免疫学 免疫学
背景情况:
- 和多醇基物质 (PFAS) 是广泛存在的环境污染物.
- 人们越来越担心PFAS暴露对健康的不利影响.
- 免疫毒性是PFAS的一个关键关注领域.
研究的目的:
- 审查PFAS免疫毒性数据在监管和临床决策中的应用.
- 评估目前的公共卫生决策是否充分考虑PFAS免疫毒性.
- 倡导在PFAS风险评估和监管中更好地整合免疫毒性数据.
主要方法:
- 关于PFAS免疫毒性的现有政府和学术文献的审查.
- 对最近关于PFAS的监管和临床决策过程的分析.
- 对在这些过程中纳入免疫毒性数据的评估.
主要成果:
- 最强有力的人类证据将PFAS暴露与疫苗接种后抗体产生减少联系起来 (例如,破伤风,角膜炎).
- 最近的监管和临床建议似乎不充分纳入了这一关键的免疫毒性数据.
- 关于PFAS免疫毒性的科学发现与其在公共卫生政策中的应用之间存在差距.
结论:
- 当前的PFAS风险评估和监管必须更有效地利用所有可用的免疫毒性数据.
- 免疫效应的生物标志物,如减少的疫苗抗体反应,应成为评估PFAS健康风险的标准.
- 对暴露于PFAS的人群的临床指南需要加强,包括免疫系统监测和保护措施.
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