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OX40/OX40联体及其在精密免疫瘤学中的作用

Bicky Thapa¹, Shumei Kato², Daisuke Nishizaki²

¹Division of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, WI, USA. bithapa@mcw.edu.

Cancer metastasis reviews

|March 25, 2024

概括

免疫检查点抑制剂显示有前途,但对有限的患者子集有益. 了解OX40和OX40L表达模式对于开发有效的OX40激动剂癌症免疫疗法至关重要.

科学领域:

免疫学免疫学免疫学
在瘤学瘤学.
分子生物学分子生物学

背景情况:

免疫检查点抑制剂 (ICI) 已经彻底改变了癌症治疗,但仅在一小部分患者中有效.
免疫逃避由PD-1和CTLA-4等点介导,而免疫刺激则涉及T细胞共刺激受体,如OX40 (CD134;TNFRSF4).
OX40受体及其配体OX40L对T细胞激活,增殖,存活,记忆形成和Treg抑制至关重要.

研究的目的:

研究OX40/OX40L轴在癌症免疫治疗中的作用.
探索OX40激动剂作为治疗策略的潜力.
了解癌症患者中OX40和OX40L的内源表达模式.

主要方法:

对免疫检查点抑制剂和免疫刺激分子的审查.
对T细胞激活和免疫调节中的OX40和OX40L功能的分析.
转录组分析,以评估癌症患者的OX40和OX40L表达.

主要成果:

OX40激动剂正在临床试验中被评估,单独和ICI,用于癌症治疗.
目前只有少数患者对OX40激动剂治疗有反应.
转录组数据表明,瘤类型和瘤类型内的OX40和OX40L表达是可变的;只有约17%的患者显示高OX40/低OX40L,这是一种潜在的响应特征.

结论:

OX40/OX40L通路是癌症免疫刺激系统的关键组成部分.
了解OX40,OX40L和共存检查点的表达模式对于精确免疫疗法至关重要.
对这些表达模式的进一步调查可能有助于开发更有效的基于OX40的癌症疗法.

关键词:

免疫治疗是一种免疫疗法.在OX40中,OX40是什么?精确瘤学是一门精确的专业.瘤亡因子受体超级家族

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