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Updated: Jun 29, 2025

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Murine Echocardiography of Left Atrium, Aorta, and Pulmonary Artery
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左心室透静功能障碍与炎症活动,功能障碍和肝脏相关死亡率的关联在患有肝硬化和的患者中
Georgios Kalambokis1, Maria Christaki1, Ilias Tsiakas1
1First Division of Internal Medicine.
European journal of gastroenterology & hepatology
|March 25, 2024
概括
在患有肝的肝硬化患者中,晚期左心室透静功能障碍 (LVDD) 与炎症,功能恶化以及肝综合征 (HRS) 和死亡风险增加有关. 早期发现LVDD对于管理这些并发症至关重要.
科学领域:
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 内部医学 内部医学
背景情况:
- 左心室扩张功能障碍 (LVDD) 是肝硬化患者常见的心脏问题.
- 需要进一步调查LVDD,全身炎症和肝与炎的临床结果之间的关系.
研究的目的:
- 检查LVDD与肝硬化和炎患者的全身炎症之间的关联.
- 确定LVDD对功能,肝综合征 (HRS) 发展和生存的影响.
主要方法:
- 预计将招募215名肝硬化和炎患者.
- 使用多普勒回声心脏学评估LVDD.
- 测量炎症标志物,全身血动力学,血管活性因子和放射性同位素评估的功能.
- 在5年内监测HRS发展和与肝脏相关的死亡率.
主要成果:
- 在66%的患者中诊断出LVDD;在43%的患者中存在2/3级LVDD.
- 血清脂聚糖结合蛋白 (LBP),血仁素活性 (PRA) 和膜过率 (GFR) 独立地与LVDD严重程度相关.
- 高度LVDD (2/3级) 与1级相比,与更高的5年HRS风险 (35.5%对14.4%) 和死亡 (53.3%对28.2%) 相关.
- 扩张功能标志物E/e'与LVDD患者的LBP,PRA和GFR有很强的相关性.
结论:
- 在肝中,LVDD的发生和严重程度与炎症活动相关.
- 先进的LVDD与循环和功能障碍有关,增加HRS和死亡的风险.
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