脑血管病理的可溶性生物标志物
Kate E Foley1,2, Donna M Wilcock1,2
1Stark Neurosciences Research Institute (K.E.F., D.M.W.), Indiana University, Indianapolis.
Stroke
|March 25, 2024
概括
对认知障碍和痴呆症 (VCID) 血管贡献的基于血液的生物标志物正在出现. 本综述探讨了有前途的候选人和正在进行的倡议,以检测VCID,这往往与阿尔茨海默病同时发生.
科学领域:
- 神经学 神经学
- 神经科学是一个神经科学.
- 生物标志物发现发现
背景情况:
- 血管对认知障碍和痴呆的贡献 (VCID) 描述了脑血管问题的认知衰退.
- VCID经常与阿尔茨海默病同时发生,使诊断和治疗复杂化.
- 目前针对阿尔茨海默病的基于血液的生物标志物已经很先进,但VCID生物标志物还处于新生阶段.
研究的目的:
- 审查目前用于识别脑血管功能障碍的基于血液的生物标志物的途径.
- 为突出VCID有希望的候选生物标志物.
- 描述正在进行的VCID基于血液的生物标志物发现的举措.
主要方法:
- 图像和病理学研究的文献综述.
- 对大脑血管功能障碍标记物的研究途径的分析.
- 目前正在进行的生物标志物发现计划的摘要.
主要成果:
- VCID是一种异质的疾病,具有不同的病理和时间特征.
- 一些有前途的血基生物标志物候选人正在出现VCID.
- 目前正在努力开发敏感和特定的VCID生物标志物.
结论:
- 开发基于血液的VCID生物标记因其患病率和与阿尔茨海默病的共患性至关重要.
- 尽管面临挑战,但在确定可靠的VCID标记物方面取得了进展.
- 未来的研究将专注于验证和实施这些生物标志物用于临床使用.
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