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下带深层大脑刺激通过差异性白质激活唤起两种不同的皮质反应
Andreas Seas1,2, M Sohail Noor1,3, Ki Sueng Choi4,5
1Department of Biomedical Engineering, Duke University, Durham, NC 27708.
抑郁症下带深脑刺激 (DBS) 激活特定的白质通道. 这项研究将独特的皮层唤起潜力 (EP) 与小子 (FM) 或带膜束 (CB) 激活联系起来,帮助优化治疗.
科学领域:
- 神经科学是一个神经科学.
- 神经外科 神经外科
- 精神病学是一个精神病学.
背景情况:
- 下环膜 (SCC) 深度大脑刺激 (DBS) 显示出治疗耐药性抑郁症的前景.
- 在SCC DBS中临床成功与激活相邻的白质有关,产生皮质唤起潜力 (EP).
- 负责驱动这些EP的特定白质路径仍然未被确定.
研究的目的:
- 为了研究哪些白质路径,特别是小子 (FM) 或带皮带 (CB),是由SCC DBS激活的.
- 为了将选择性纤维束激活与明显的皮质唤起潜力 (EPs) 相关联.
主要方法:
- 用个性化的生物物理模型来准FM或CB.
- 单边2 Hz刺激被应用于7名患有治疗耐药抑郁症的患者,这些患者对SCC DBS有反应.
- 256传感器头皮脑电图记录了皮质唤起的潜能 (EP).
主要成果:
- 确定了两个不同的EP:一个120毫秒的对称响应和一个60毫秒的不对称响应.
- 小子 (FM) 的激活与对称的EPs相关.
- 带束 (CB) 的激活与不对称的EPs相关.
结论:
- 这些发现支持模型对临床SCC DBS主导激活FM和CB的预测.
- 这项研究提供了第一个直接证据,将特定的皮层唤起潜力与SCC DBS中独特的白质纤维束的选择性激活联系起来.
- 了解这些途径-EP关系可以改进DBS向,以改善抑郁症治疗结果.
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