相关实验视频

Updated: Jun 29, 2025

A 3D Organotypic Melanoma Spheroid Skin Model

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

第三阶段可切除黑色素瘤的治疗 - 辅助和新辅助方法

Ahmad A Tarhini¹, Ella Castellano, Islam Eljilany¹

¹From the H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL.

Cancer journal (Sudbury, Mass.)

|March 25, 2024

概括

对于III期黑色素瘤患者,新辅助疗法比辅助疗法更有前途. 这种方法针对微转移性疾病,有可能减少复发并改善晚期黑色素瘤病例的存活率.

科学领域:

在瘤学瘤学.
免疫治疗是一种免疫疗法.
黑色素瘤研究黑色素瘤研究

背景情况:

仅仅在手术后,III期切除性黑色素瘤的复发风险很高 (40-90%).
辅助疗法旨在消除微转移性疾病,以防止复发.
之前的辅助试验显示,使用干素α和伊皮利姆巴有好处.

研究的目的:

评估现代辅助和新辅助疗法对III期切除性黑色素瘤的疗效.
为了在黑色素瘤患者中比较新辅助疗法和辅助疗法.

主要方法:

对辅助免疫疗法 (pembrolizumab,nivolumab) 和向治疗 (dabrafenib-trametinib) 的随机第三期试验的审查.
对局部区域性晚期黑色素瘤的新辅助全身疗法新出现的数据的分析.
考虑最近的一项合作性小组试验 (S1801),比较新辅助和辅助方法.

主要成果:

辅助 pembrolizumab 和dabrafenib-trametinib 与安慰剂相比改善了无复发的生存时间.
新辅助药尼沃卢马布和潘布罗利祖马布改善了无复发的存活率,而非伊皮利穆马布10毫克/公斤.
试验S1801报告了与辅助治疗相比,新辅助治疗的无事件生存率优越.

结论:

新辅助免疫疗法和向疗法正在成为重要的治疗选择.
目前的数据表明,在符合条件的黑色素瘤患者中,转向新辅助疗法.
与传统的辅助疗法相比,新辅助疗法可能提供更好的结果.

更多相关视频

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine

Published on: February 24, 2023

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing Neoadjuvant Therapies

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing Neoadjuvant Therapies

Published on: July 28, 2020

相关概念视频

Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.