瘤透性淋巴细胞和其他细胞疗法用于转移性黑色素瘤
Christy Los1, Sebastian Klobuch2, John B A G Haanen
1From the Division of Molecular Oncology and Immunology, Oncode Institute, Netherlands Cancer Institute.
Cancer journal (Sudbury, Mass.)
|March 25, 2024
概括
收养细胞疗法,包括瘤透性淋巴细胞,对其他治疗不起作用的晚期黑色素瘤患者显示有前途. 转基因T细胞的进一步进展可能会改善耐火病例的结果.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 细胞疗法细胞疗法
背景情况:
- 通过免疫检查点抑制剂和向疗法,晚期黑色素瘤的存活率得到了改善.
- 没有反应或复发性黑色素瘤的患者仍然面临着不良预后.
研究的目的:
- 审查黑色素瘤中采用T细胞疗法的历史发展,当前状况和未来前景.
- 突出瘤透淋巴细胞和转基因T细胞在晚期黑色素瘤中的潜力.
主要方法:
- 对黑色素瘤采用细胞疗法的临床试验数据的审查.
- 讨论瘤透淋巴细胞输液的疗效.
- 探索转基因T细胞策略,包括T细胞受体和仿真抗原受体.
主要成果:
- 瘤透淋巴细胞输液可以在高达50%的晚期黑色素瘤患者中产生反应,这些患者在抗编程细胞死亡1疗法上进展.
- 在接受瘤透淋巴细胞治疗的患者中,多达20%的患者观察到持久的完整反应.
- 在耐火性黑色素瘤群体中,转基因T细胞具有改善结果的潜力.
结论:
- 采用T细胞疗法是晚期黑色素瘤的重大进展,特别是对于选择有限的患者.
- 对转基因T细胞疗法的进一步研究有可能改善耐火性黑色素瘤的治疗结果.
- 该审查强调了基于细胞的治疗方法在黑色素瘤管理中的不断变化的景观和未来潜力.
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