专家小组就在泰国使用 nebulized budesonide 治疗喘和 COPD 在稳定阶段和恶化阶段的建议达成共识
Phunsup Wongsurakiat1, Akrawat Rattanawongpaibul2, Atikun Limsukon3
1Division of Respiratory Diseases and Tuberculosis, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
雾化布德索尼德有效治疗成人喘和COPD恶化和维持. 它为全身性皮质类固醇提供了耐受性良好的替代品,减少了不良影响并改善了结果.
科学领域:
- 肺部病理学 肺部病理学
- 药理学 药理学是指药理学的学科.
背景情况:
- 喘和COPD恶化需要有效的治疗.
- 系统性皮质类固醇 (SCS) 是标准的,但有不良影响.
- 雾化布德索尼德是一种潜在的替代品.
研究的目的:
- 调查 nebulized budesonide 对急性恶化和成人喘和 COPD 维持治疗的疗效.
- 将其安全性和有效性与标准治疗方法进行比较.
主要方法:
- 在PubMed.com上进行了系统的文献搜索.
- 包括使用特定Mesh术语的英语临床研究 (RCT,观察性,现实世界).
- 分析了25项研究,重点关注喘和COPD中的 nebulized budesonide.
主要成果:
- 雾化布德索尼德在治疗喘和COPD方面表现出有效性.
- 耐受性很好,系统性不良反应比SCS少.
- 高剂量的 nebulized budesonide 改善了严重恶化的结果,并可以替代 SCS.
结论:
- 雾化布德索尼德是一种有效和安全的治疗选择,用于成人喘和COPD.
- 它可以作为SCS的辅助或替代品,提供更好的安全性.
- 建议支持将其纳入标准护理指南.
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