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Positron Emission Tomography01:29

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Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
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Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
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一个更新的变量RBE模型用于质子疗法.

Erlend Lyngholm1, Camilla Hanquist Stokkevåg1,2, Armin Lühr3

  • 1Department of Physics and Technology, University of Bergen, Bergen, Norway.

Physics in medicine and biology
|March 25, 2024
PubMed
概括

一个新的更新的质子相对生物有效性 (RBE) 模型是使用最大的可用的体外数据库开发的. 该模型证明了在临床环境中对质子疗法评估RBE的性能有所改善.

关键词:
在RBE建模中,使用RBE模型.在体外数据 in vitro数据.质子疗法是一种质子疗法.

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科学领域:

  • 医学物理 医学物理
  • 辐射瘤学 辐射瘤学
  • 放射生物学的放射生物学

背景情况:

  • 临床质子疗法传统上使用1.1的恒定相对生物效率 (RBE).
  • 越来越多的可变RBE模型被用于治疗计划的评估,但现有的模型显示显著的变化和缺乏更新的体外数据.
  • 需要精细的RBE模型,将当前的实验发现纳入其中.

研究的目的:

  • 编制一个更新的体外质子RBE数据库.
  • 分析当前现象学RBE模型的假设.
  • 为临床评估提出一个新的,最新的RBE模型.

主要方法:

  • 从文献中收集了471个数据点的质子RBE数据库,其中包括线性二次模型参数和线性能量转移 (LET).
  • 进行统计分析以验证RBE模型假设,并为RBEmax和RBEmin提出了新的功能.
  • 将现有模型重新安装到数据库中,并将其性能与新开发的模型进行比较.

主要成果:

  • 统计分析表明,RBEmax函数的截取值应该是一个自由拟合参数,从而导致更高的RBE估计值.
  • 随着LET的增加,RBEmin的增加,以及它对参考辐射分化灵敏度 (α/βx) 的依赖,并没有显著改善模型性能.
  • 新的RBE模型表现出最低的根平均平方误差 (RMSE) 和最高的R2得分,超过了重新装配的现有模型.

结论:

  • 基于现有最大的现象学模型数据库,成功开发了更新的RBE模型.
  • 与重新装配的已公布的RBE模型相比,拟议的模型表现出优越的性能.
  • 这种新模型是评估临床质子疗法中RBE效应的宝贵工具.