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Updated: Jun 29, 2025

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拉洛西芬驱动的乙烯衍生物:发现,结构提炼和生物评估作为基于药物重新定位的强大的PPARγ调节器

Qingmei Liu1, Lei Ma1, Fangyuan Chen1

  • 1Guangdong Provincial Key Laboratory of Molecular Target and Clinical Pharmacology, The State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, Guangdong, 511436, China.

European journal of medicinal chemistry
|March 25, 2024
PubMed
概括

研究人员重新设计了骨质疏松症药物拉洛西芬,发现了YGL-12,一种新的PPARγ部分激动剂. 这种化合物在没有常见副作用的小鼠中有效降低血糖,为2型糖尿病提供了有前途的新疗法.

关键词:
(S) -VSP-77 (PubChem CID) 是一个非常重要的技术.) 在此之前,我们已经看到了.139267749) 的一个地方.16131098 年的第一千六百一十三年.3 - 异布-1-甲基丁 (PubChem CID: 3758) 的使用情况5743年) 的情况.西奥芬衍生物的西奥芬衍生物德克萨米他 (PubChem CID) 的使用情况甲基二硫氧化物 (PubChem CID: 679) 是一种葡萄糖 (PubChem CID:5793) 的使用情况胰岛素 (PubChem CID:PubChem CID:PubChem CID:PubChem CID:PubChem CID:PubChem CID:PubChem CID:PubChem CID:PubChem CID:PubChem CID:PubChem CID:PubChem CID:PubChem CID:PubChem CID:PubChem CID:PubChem CID:PubChem CID:PubChem CID:PubChem CID:PPPARγ Ser273 的酸化方式拉洛西芬 (PubChem CID:5035) 的使用情况罗西格利塔 (PubChem CID: 77999) 的使用情况这就是SPPARγM的原因.结构优化 结构优化基于结构的虚拟选.这就是T2DM.

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