早期结核病状态的分类,以指导改善护理和预防的研究:国际德尔菲共识练习
Anna K Coussens1, Syed M A Zaidi2, Brian W Allwood3
1Infectious Diseases and Immune Defence Division, The Walter and Eliza Hall Institute of Medical Research (WEHI), Parkville, VIC, Australia; Centre for Infectious Diseases Research in Africa, University of Cape Town, Cape Town, South Africa; Institute of Infectious Disease and Molecular Medicine, and Department of Pathology, University of Cape Town, Cape Town, South Africa; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia.
一个新的结核病分类框架 - - 早期结核病国际共识 (ICE-TB) - - 已经开发出来,以解决疾病的范围. 该框架旨在统一术语和诊断标准,以推进结核病研究和消除努力.
科学领域:
- 传染性疾病 传染性疾病
- 微生物学 微生物学
- 公共卫生 公共卫生
背景情况:
- 结核病 (TB) 的活跃潜伏模式未能涵盖疾病的全部范围.
- 不一致的定义和诊断标准阻碍了结核病研究和消除结核病的产品开发.
- 实用性研究和实施需要简化,全面的分类.
研究的目的:
- 开发一个新的框架来分类结核病的状态.
- 为了适应关键疾病状态,同时确保研究和实施的简单性.
- 建立关于概念状态,术语和研究差距的共识.
主要方法:
- 一个国际的Delphi演习,涉及71个多学科的参与者.
- 参与者代表了不同的学科,部门,收入设置和地理位置.
- 在疾病状态,术语和研究优先事项上建立共识.
主要成果:
- 建立了早期结核病国际共识 (ICE-TB) 框架.
- ICE-TB基于宏观病理学来区分结核病与感染.
- 定义了两个亚临床和两个临床结核病状态,考虑症状,迹象和传染性.
结论:
- ICE-TB框架为了解结核病病态提供了一种统一的方法.
- 它澄清了感染和疾病的先决条件,包括可行的Mycobacterium结核病和宿主反应.
- 该框架为结核病研究,临床护理和消除政策提供了方向.
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