一种健康的饮食模式与最近被诊断为双极性患者的微生物群多样性有关:荷兰双极性队列 (BINCO) 研究
M A Riedinger1, R Mesbah2, M Koenders3
1Department of Psychiatry, Leiden University Medical Center, Leiden, the Netherlands; Psychiatric Institute, GGZ Rivierduinen, Outpatient Clinic for Mental Disability and Psychiatry, Leiden, the Netherlands.
Journal of affective disorders
|March 25, 2024
概括
健康的饮食与双极性障碍 (BD) 患者的肠道微生物群多样性更大有关. 饮食质量和肠道微生物群多样性在BD治疗的第一年保持稳定.
科学领域:
- 肠-大脑轴研究研究
- 微生物组研究研究.
- 心理健康和营养问题
背景情况:
- 饮食显著影响肠道微生物群的组成和功能.
- 肠-大脑轴将肠道健康与精神和身体健康联系起来.
- 饮食,肠道微生物群和双极性障碍 (BD) 之间的关系仍未得到充分研究.
研究的目的:
- 调查最近被诊断为BD患者的饮食质量和肠道微生物群多样性之间的关联.
- 检查在BD治疗的第一年饮食质量和肠道微生物群多样性的变化.
主要方法:
- 七十名最近被诊断为BD的患者被招募为荷兰双极性队列 (BINCO) 研究.
- 通过203项食物频率问卷 (FFQ) 评估饮食摄入量,计算荷兰健康指数 (DHD-15).
- 从便样本中分析了肠道微生物群的组成和多样性,在基线和1年随访时使用16S rRNA基因扩增序列测序.
主要成果:
- 较高的饮食质量 (DHD-15总得分) 与增加的肠道微生物群α多样性 (香农指数),丰富性 (Chao1指数) 和均性 (Pielou的均性指数) 显著相关,在对共变量进行调整后.
- 积极的相关性主要是由鱼类,豆类,水果和坚果的消费驱动的,对酒精和加工肉类观察到的反向相关性.
- 在定期治疗的一年随访期间,没有观察到饮食质量或肠道微生物群多样性的显著变化.
结论:
- 健康多样化的饮食与双极性障碍患者的肠道微生物群多样性更大有关.
- 需要进行进一步的研究,以探索这些发现对 BD 患者情绪稳定性和整体健康的影响.
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