胚胎的长期储存不会影响辅助生殖技术的结果:分析了11年来58,001个玻璃化胚胎囊
Ana Cobo1, Aila Coello1, María J De Los Santos1
1IVIRMA Global Research Alliance, Valencia, Spain; IVI Foundation, Health Research Institute La Fe, Valencia, Spain.
American journal of obstetrics and gynecology
|March 25, 2024
概括
玻璃化胚胎囊的长期储存不会影响冷胚胎移植中的活产率. 其他因素,如患者年龄和胚胎质量,对于成功的结局更为重要.
科学领域:
- 生殖医学 生殖医学
- 胚胎学 胚胎学
- 在体外受精过程中受精.
背景情况:
- 有关长期储存对玻璃化胚胎生存能力的影响存在担忧.
- 一些研究表明,冷存储时间和临床成功率降低之间存在联系.
研究的目的:
- 为了评估储存时间对第5天玻璃化胚胎囊的影响.
- 为了比较冷周期和非选择性冷胚胎移植的结果.
主要方法:
- 在11年的时间里,对58,001个玻璃化/加热的第5天芽细胞囊进行了回顾性分析.
- 根据储存时间 (全结≤0.67至≥4.34个月,非选择性≤1.8至≥34.81个月) 将胚胎囊细胞分类为分类.
- 单变量和多变量逻辑回归分析评估活产率,胚胎存活率,流产和怀孕率.
主要成果:
- 胚胎存活率在两组的所有储存时间都是一致的.
- 生产率在储存子组中显示出一些变化,但多变量分析显示没有与储存时间的显著关联.
- 囊胚质量,患者的BMI和卵细胞产量等因素影响了活产率.
结论:
- 玻璃化母细胞囊的延长存储时间不会对临床结果产生负面影响.
- 患者年龄,胚胎质量和其他临床因素对活产率的影响更大.
- 这项研究支持长期胚胎玻璃化用于辅助生殖的安全性和有效性.
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