尿和尿病:一个系统的审查和元分析
Yuan-Hsin Chen1, Chih-Fu Wei1, Ya-Yun Cheng2
1Department of Environmental Health, Harvard T.H. Chan School of Public Health, 677 Huntington Ave, Boston, MA 02115, United States.
Environmental research
|March 25, 2024
概括
暴露与更高的尿结石 (结石) 风险有关. 即使小便中的含量略有增加,也会显著增加这种风险,突出显示减少暴露的必要性.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 暴露于是越来越严重的环境问题.
- 以前的研究表明,与尿病之间存在潜在的联系,但这些发现是不一致的.
研究的目的:
- 系统地审查和元分析暴露与发生尿病的风险之间的关联.
主要方法:
- 在主要的科学数据库中进行了搜索 (Medline/PubMed,Embase,科学网,Cochrane中央).
- 包括8项观察性研究,包括39个研究群体 (63,051名受试者).
- 使用聚合相对风险 (RR) 分析了尿病的发病率.
主要成果:
- 尿中的0.1μg/g肌素增加与2%更高的尿病风险相关 (RR:1.02,CI:1.01-1.03).
- 尿中的含量增加0.1μg/L与尿病风险增加4%相关 (RR: 1.04,CI: 1.02-1.07).
- 关联在性别,地区和人口 (一般和职业) 之间是一致的.
结论:
- 暴露与尿病的风险增加有显著关联.
- 尽量减少环境和职业暴露对公共健康至关重要.
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