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甲基四博二甲具有甲状腺破坏作用,但对产后大脑发育和小鼠神经行为几乎没有明显的影响

Shilin Song¹, Yuanyuan Li¹, Lin Lv¹

¹State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; College of Resources and Environment, University of Chinese Academy of Sciences, Beijing 100049, China.

Journal of environmental sciences (China)

|March 25, 2024

概括

一种阻燃剂Tetrabromobisphenol A (TBBPA) 在小鼠中引起甲状腺干扰,但对大脑发育和神经行为影响很小. 在这项研究中,甲状腺功能障碍并没有导致明显的不良神经发育结果.

科学领域:

环境毒理学环境毒理学
内分泌学在内分泌学.
神经科学是一个神经科学.

背景情况:

甲二烯A (TBBPA) 是一种常见的制阻燃剂,具有备受争议的甲状腺破坏性和神经毒性作用.
对TBBPA内分泌和神经毒性潜力的哺乳动物研究产生了不一致的结果.

研究的目的:

为了研究TBBPA在雄性小鼠中的甲状腺破坏作用和神经毒性.
通过饮用水对母亲和直接暴露后评估TBBPA的影响.

主要方法:

作为阳性对照,雄性小鼠被暴露在TBBPA (5,50,500微克/天) 或propylthiouracil (PTU) 中.
甲状腺组织学,血清激素水平,小脑发育和神经行为参数在不同的时间点被评估.

主要成果:

TBBPA诱导甲状腺组织学变化并降低甲状腺激素水平,特别是在较高剂量时.
在暴露于TBBPA时,没有观察到对小脑发育 (Purkinje细胞,层厚) 的显著影响.
在最高的TBBPA剂量下,人们注意到过渡的焦虑类行为和血清激素的降低,但这些问题在成年后得到解决.

结论:

在小鼠中,TBBPA表现出破坏甲状腺的特性.
TBBPA似乎不会导致明显的不良神经发育结果或持续的神经行为变化.
由TBBPA引起的甲状腺干扰不一定会导致显著的神经发育缺陷.

关键词:

大脑发育大脑发育大脑小部分的大脑小部分神经行为神经行为.基双甲甲甲甲基双甲甲甲甲甲甲甲甲甲甲甲甲甲甲甲甲甲甲甲甲甲甲甲甲甲甲甲甲甲甲甲状腺功能障碍甲状腺功能障碍

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