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Updated: Jun 29, 2025

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一种转录激活域的脂皮多米米特选择性地破坏了同活性剂Med25的蛋白质-蛋白质相互作用

Olivia N Pattelli1,2, Estefanía Martínez Valdivia1,2, Matthew S Beyersdorf1,2

  • 1Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.

Angewandte Chemie (International ed. in English)
|March 25, 2024
PubMed
概括

像LPPM-8这样的脂类胺基药可以通过脂肪酸进行修改,以有效抑制Med25蛋白质与蛋白质的相互作用. 这一进步为研究Med25生物学和三阴性乳腺癌提供了新的工具.

关键词:
辅助激活剂的使用方法这是一种脂类.在Med25中,有25人.蛋白蛋白相互作用抑制剂.转录因子是一种转录因子.

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