对多发性硬化症中社会认知障碍的系统审查和元分析
Mandy Roheger1,2, Lydia Grothe1, Laura Hasselberg1
1Department of Neurology, University Medicine Greifswald, Walther Rathenau Str. 49, 17489, Greifswald, Germany.
Scientific reports
|March 26, 2024
概括
多发性硬化症 (MS) 显著影响社会认知,特别是情感思维理论 (aToM). 疲劳会加剧MS患者的认知思维理论 (cToM) 缺陷.
科学领域:
- 神经科学是一个神经科学.
- 心理学 心理学 心理学
- 临床医学 临床医学
背景情况:
- 社会认知障碍在多发性硬化症 (MS) 中很常见,影响社会互动和决策.
- 在MS中,特定的临床症状 (认知,抑郁,疲劳) 和社会认知缺陷之间的关系尚不清楚.
- 这些缺陷背后的神经机制需要进一步阐明.
研究的目的:
- 通过元分析量化MS中的社会认知障碍.
- 研究临床症状对社会认知缺陷的影响.
- 探索MS中社会认知障碍的神经基础.
主要方法:
- 在主要数据库 (MEDLINE,科学网,CENTRAL,PsycInfo) 进行系统的文献搜索,直到2022年12月.
- 包括对MS患者与对照者的情感/认知思维理论 (a/cToM),视觉视角采用 (VPT) 和社会决策 (SDM) 的研究.
- 使用CLARITY小组工具进行偏差风险评估;对临床症状影响进行调解分析;回顾神经影像研究.
主要成果:
- 分析证实,MS患者的aToM和cToM都显著受损,aToM的缺陷更大.
- 调解分析显示,疲劳是cToM损伤的重要预测因素.
- 神经成像研究显示了大量的异质性,限制了对神经相关的最终结论.
结论:
- 多发性硬化与实质性的社会认知障碍有关,特别是在情感和认知思维理论中.
- 临床症状,特别是疲劳,可能会加剧特定的社会认知缺陷.
- 未来的研究需要大规模的协调研究,评估MS中的社会认知参数,调解器和神经相关物.
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