疾病修饰疗法的治疗满意度是来自上埃及多发性硬化症患者坚持治疗的唯一预测因素
Eman M Khedr1,2, Doaa M Mahmoud3, Hussein B Hussein4
1Department of Neuropsychiatry, Faculty of Medicine, Assiut University Hospital, Asyût, Egypt. Emankhedr99@yahoo.com.
Scientific reports
|March 26, 2024
概括
在上埃及,多发性硬化症 (MS) 疾病修饰疗法 (DMT) 的不遵守率仍然很高. 在这组患者中,较低的治疗满意度是DMT不遵守的唯一预测因素.
科学领域:
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 疾病修饰疗法 (DMT) 对于治疗多发性硬化症至关重要.
- 在全球范围内,不坚持DMT的高比例是一个重大挑战,影响治疗疗效.
- 了解上埃及等特定人群的坚持因素对于改善患者的治疗结果至关重要.
研究的目的:
- 确定在上埃及的RRMS患者中第一个DMT的不遵守率.
- 为了确定在这个人群中导致DMT不坚持的因素.
- 评估坚持和临床因素之间的关系,包括残疾,抑郁,疲劳和睡眠质量.
主要方法:
- 研究了一组来自上埃及三个多发性硬化病单位的97名成年RRMS患者.
- 收集的数据包括临床病史,EDSS,MMAS-8的坚持,TSQM-9的满意度,以及抑郁症,疲劳和睡眠质量的尺度.
- 包括回归在内的统计分析被用来识别不遵守的预测因素.
主要成果:
- 64.9%的患者表现出不遵守他们的第一个DMT,用MMAS-8.8测量.
- 不坚持与更长的疾病持续时间,第一次DMT更长的持续时间,更早的DMT开始日期和更低的治疗满意度有关.
- 在回归分析中,较低的治疗满意度是DMT不坚持治疗的唯一显著预测因素.
结论:
- 对于上埃及的多发性硬化症患者来说,不遵守一线DMT仍然是一个重大问题.
- 对治疗的满意度是影响DMT在这个人群中的坚持的关键因素.
- 定期评估坚持和治疗满意度对于优化DMT对MS患者的益处至关重要.
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