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Updated: Jun 29, 2025

Infection of Primary Nasal Epithelial Cells Grown at an Air-Liquid Interface to Characterize Human Coronavirus-Host Interactions
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SARS-CoV-2包膜蛋白损害了呼吸道上皮质屏障功能,并通过增加细胞内Cl-度加剧呼吸道炎症

Jian-Bang Xu1, Wei-Jie Guan2,3,4, Yi-Lin Zhang5,6

  • 1State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Department of Respiratory and Critical Care Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, P. R. China.

Signal transduction and targeted therapy
|March 26, 2024
PubMed
概括

SARS-CoV-2 E 蛋白质会损害气道上皮屏障,并通过破坏化物运输来加剧炎症. 阻止SGK1或PDE4可以减少这种E蛋白诱导的炎症.

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