经过重复的社会压力后的选择冲动性与中部前额叶皮层中围神经网络增加有关
Christopher A Martinez1, Harry Pantazopoulos2, Barbara Gisabella2
1HESRM, School of Applied Sciences, University of Mississippi, Oxford, MS, USA.
Scientific reports
|March 26, 2024
概括
重复的压力,以间歇性社会失败 (ISD) 为模式,增加了中间前额叶皮质 (mPFC) 中的选择冲动性和皮质抑制. 这些变化可能会使动物在压力后易于滥用物质.
科学领域:
- 神经科学是一个神经科学.
- 行为神经科学 行为神经科学
- 成研究 研究成研究
背景情况:
- 重复的压力是药物滥用的已知危险因素.
- 具体的行为和神经生物学机制将压力与成联系在一起仍然不完全理解.
- 间歇性社会失败 (ISD) 是一种经过验证的动物模型,用于促进寻求药物行为的压力.
研究的目的:
- 研究ISD对时间间决策 (选择冲动性) 的影响.
- 为了检查ISD后在中间前额叶皮层 (mPFC) 中皮层抑制功能的改变.
- 为了确定ISD诱导的决策和皮质抑制的变化是否与寻求奖励的行为相关.
主要方法:
- 雄性Long-Evans老鼠接受了延迟折扣任务 (DDT) 的训练,以评估选择冲动性.
- 鼠被暴露于间歇性社会失败 (ISD),并在压力后的不同时间点对DDT进行了测试.
- 免疫组织化学被用来量化mPFC中的周神经网络 (PNN) 和帕瓦胺 (PV) 内神经元作为抑制功能的标记物.
主要成果:
- 在低冲动性老鼠中,ISD显著减少了对延迟奖励的偏好,这表明选择冲动性增加了.
- 暴露于ISD导致mPFC中围神经网络 (PNN) 密度显著增加.
- 这些对决策和PNN的影响在最后的压力事件发生一周和两周后被观察到.
结论:
- 间歇性社会失败 (ISD) 诱导了决策和皮质抑制标记在中间前额叶皮质 (mPFC) 的持久变化.
- 压力后增加的选择冲动性和改变的皮质抑制可能代表神经生物学适应,使个人倾向于滥用药物.
- 这些发现强调了压力诱导的冲动性和mPFC功能障碍在过渡到成中的作用.
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