一项随机对照研究,评估莫萨普里德酸盐对胃切除术后肠道恢复的影响
Shiyeol Jun1, Seyeol Oh1, Ji Eun Jung1
1Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
Scientific reports
|March 26, 2024
概括
莫萨普里德酸盐在经过胃癌的微创性胃切除术后在手术后增强恢复 (ERAS) 协议中没有改善肠道恢复. 对于这些患者,不建议常规使用这种 prokinetic 药物.
科学领域:
- 胃肠病学 胃肠病学
- 手术瘤学手术瘤学
- 药理学 药理学是指药理学的学科.
背景情况:
- 手术后增强恢复 (ERAS) 协议旨在优化术后患者的康复.
- 催化剂药物经常被纳入ERAS协议中,以预防手术后的阴.
- 在ERAS中,关于莫萨普里德酸盐在胃切除患者的疗效的证据有限.
研究的目的:
- 评估莫萨普里德酸盐在胃癌微创性胃切除术后增强肠移动性恢复方面的有效性.
- 评估莫萨普里德酸盐对ERAS协议下胃切除术的患者肠道恢复关键参数的影响.
主要方法:
- 进行了一项双盲随机对照试验,涉及为胃癌进行腹腔镜或机器人胃切除术的患者.
- 参与者在术后1-5天接受莫萨普里德酸盐或安慰剂.
- 评估了肠道运动,使用放射性不透明的标记物来评估过渡时间,到第一次浮的时间和食物摄入.
主要成果:
- 在莫萨普里德酸盐和安慰剂组之间的基线特征中没有发现显著差异.
- 在手术后的第3天,结肠中的放射性色标记物表明了肠道过渡时间,没有显著差异.
- 关键的恢复指标包括时间到第一次浮,住院时间,食物摄入量和腹部不适在各组之间是相似的.
结论:
- 莫萨普里德酸盐在为胃癌进行微创性胃切除术后加速肠移动性恢复方面没有显示好处.
- 对于在ERAS框架内接受此程序的患者,不建议对莫萨普里德酸盐进行常规的术后治疗.
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