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Updated: Jun 29, 2025

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在临床上观察到的FOXA1突变通过前列腺癌的转录性脱抑来提高SEMA3C的调节

Kevin J Tam1, Liangliang Liu1, Michael Hsing1

  • 1Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada.

Scientific reports
|March 26, 2024
PubMed
概括

在前列腺癌中,FOXA1转录因子的突变会增加Semaforin 3C (SEMA3C) 水平. 这表明SEMA3C可能会驱动瘤生长和转移性割抵抗性前列腺癌 (mCRPC) 的治疗耐药性,具有FOXA1变异.

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