急性大麻 (CBD) 使用是否会影响表现? 一个元分析和与安慰剂和delta-9-tetrahydrocannabinol (THC) 的比较
Lindsay A Lo1,2, April L Christiansen3, Justin C Strickland4
1Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
概括
根据对人类实验室研究的元分析,大麻素 (CBD) 可能会引起轻微镇静,但不会损害认知或精神运动性能. 急性CBD使用不太可能影响日常功能.
科学领域:
- 药理学和毒理学 药理学和毒理学
- 神经科学是一个神经科学.
- 人类表现研究研究 人类表现研究
背景情况:
- 大麻 (CBD) 被广泛认为是无毒的,没有急性性能影响.
- 现有的数据尚未综合,以最终评估CBD对表现的影响.
- 鉴于其日益普及和使用,了解CBD的急性影响至关重要.
研究的目的:
- 系统地综合控制的人类实验室研究中关于急性CBD使用和性能的数据.
- 评估与安慰剂相比,急性CBD消费是否会损害认知和精神运动性能.
- 为了比较CBD与delta-9-tetrahydrocannabinol (Δ9-THC) 的性能效应,作为积极对照.
主要方法:
- 成人临床试验的元分析,评估急性CBD影响 (0-8小时后给药).
- 包括测量客观和主观认知和精神运动表现的研究.
- 使用强大的方差估计 (RVE) 元回归计算聚合效应大小.
主要成果:
- 一个统计学上显著的,小效果大小 (Hedges' g = 0.122) 表示急性CBD与安慰剂 (N=16项试验) 的性能受损.
- 主观测量,特别是自我报告的镇静 (Hedges' g = 0.288),显示出比客观性能任务 (Hedges' g = 0.048) 更大的差异.
- 与CBD相比,delta-9-tetrahydrocannabinol (Δ9-THC) 显示出明显更大的损伤大小 (N=8个试验,Hedges的g = 0.416).
结论:
- 急性CBD消费与主观镇静的轻微增加有关,但不会损害客观评估的认知或精神运动性能.
- 这些发现表明,单独使用CBD不太可能显著损害日常功能或工作场所的表现.
- 而CBD的性能效应显著低于Δ9-THC.
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