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在阿拉比多普西斯NLR中,高等位基因多样性与独特的基因组特征有关

Chandler A Sutherland¹, Daniil M Prigozhin², J Grey Monroe³

¹Department of Plant and Microbial Biology, University of California Berkeley, Berkeley, CA, 94720, USA.

|March 26, 2024

概括

高度可变的植物免疫受体 (hvNLRs) 由于表达更高,DNA甲基化较少以及接近移动遗传元素,因此表现出更大的多样性. 这种多样性是由进化选择维持的,与它们的保存对应物不同.

科学领域:

植物免疫力植物免疫力
分子进化是分子进化的过程.
基因组学和表观基因组学

背景情况:

植物利用核酸结合,富含白素的重复受体 (NLR) 来检测病原体.
高度可变的NLRs (hvNLRs) 显示出显著的物种内部多样性,与在生态型中发现的保存,低变量的非hvNLRs形成鲜明对比.

研究的目的:

调查与植物NLRs中的等位基因多样性相关的基因组和表观基因组特征.
了解维护hvnlr多样性的进化机制.

主要方法:

在Arabidopsis Col-0.中对NLR进行比较分析.
评估基因表达,DNA甲基化和可转移元素的接近性.
核酸多样性和选择压力的评估 (多样化和净化选择).

主要成果:

与非hvNLR相比,hvNLRs表现出更高的表达,减少了基因体细胞因子甲基化,并且与可转移元素更接近.
hvNLRs显示同义和非同义核酸多样性的增加,并且位于易发生突变的染色体区域.
多样化选择对hvnlr编码子起作用,而净化选择保护非hvnlrs.

结论:

基因组和表观基因组特征,包括表达水平和染色质状态,有助于建立和维护hvnlr多样性.
进化选择压力在hvNLR和非hvNLR之间有所不同,导致不同的变异模式.
了解这些因素对于理解植物先天免疫受体多样性的演变至关重要.

关键词:

进化进化进化进化进化进化进化基因组特征基因组特征豁免权是一种豁免权.结合核酸的氨酸丰富重复受体 (NLRs)

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