组合营养补充剂降低了DNA甲基化年龄,只有在年长的成年人中,表观遗传年龄提高了
Kirsty C McGee1, Jack Sullivan1, Jon Hazeldine1
1MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.
GeroScience
|March 26, 2024
概括
12周的营养补充剂减少了老年人的表观遗传年龄和炎症,加快了衰老. 这表明,对于那些经历炎症和先进的生物衰老的人来说,可能有好处.
科学领域:
- 老年学和营养科学研究
- 表观遗传学和衰老研究研究.
背景情况:
- 系统性炎症或炎症是衰老过程的一个关键特征.
- 基于DNA甲基化的表观遗传钟可以测量生物年龄,并且可能是可逆的.
- 正在探索营养干预措施,以减轻与年龄相关的生物衰退.
研究的目的:
- 评估多成分营养补充剂对健康老年人系统性炎症和表观遗传年龄的影响.
- 调查补充剂是否可以逆转表观遗传衰老加速并减少炎症标志物.
主要方法:
- 80名健康的老年人接受了为期12周的补充剂 (维生素B3,C,D,欧米茄-3,白醇,橄类,阿斯塔桑丁).
- 血液和唾液样本是在补充剂前和后收集的.
- 分析了炎症标志物 (CRP,GDF-15) 和表观遗传年龄 (使用Horvath,Hannum和InflammAge时钟).
主要成果:
- 基于血液的时钟或基于唾液的InflammAge时钟没有检测到表观遗传年龄的整体变化.
- 具有基线表观遗传年龄加速 (≥2年) 的参与者使用InflammAge时钟显著减少了表观遗传年龄和加速.
- 在心血管疾病风险较高的参与者 (hsCRP ≥3μg/ml) 中观察到C反应蛋白 (CRP) 的降低.
结论:
- 联合营养补充剂可能有利于加速表观遗传衰老和炎症的个体.
- 基于唾液的InflammAge时钟在参与者的小组中发现了表观遗传年龄的逆转.
- 需要进一步的研究来证实这些发现并阐明作用机制.
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