普遍存在的环境化学物质损害了寡细胞的发展
Erin F Cohn1, Benjamin L L Clayton1, Mayur Madhavan1
1Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Nature neuroscience
|March 26, 2024
概括
环境中的化学物质可能会损害大脑发育. 这项研究发现四级化合物和有机酸盐阻燃剂扰乱了寡细胞的发育,影响了神经发育,并突出了普通家用产品带来的风险.
科学领域:
- 神经科学是一个神经科学.
- 毒理学 毒理学 毒理学
- 环境健康 环境健康
背景情况:
- 寡头细胞的发育对于神经发育至关重要,并延伸到成年期.
- 环境化学物质暴露对寡细胞构成潜在的风险,但很少有人进行评估.
- 了解这些风险对于公共健康和神经发育结果至关重要.
研究的目的:
- 为了识别破坏寡头细胞发育的环境化学物质.
- 阐明这些化学物质影响寡细胞成熟的独特机制.
- 评估已识别的化学物质对神经发育的体内和体外影响.
主要方法:
- 在培养细胞中对环境化学品进行高通量选.
- 利用细胞培养,小鼠模型和人类3D器官模型用于产前皮层发育.
- 分析流行病学数据以将化学物质暴露与神经发育结果相关联.
主要成果:
- 发现四次性化合物对发育中的寡细胞具有细胞毒性.
- 已确定有机酸盐阻燃剂可以提前阻止寡类细胞的成熟.
- 这两类化学物质都在体内和人体器官模型中损害了寡细胞的发育,流行病学上与不良神经发育结果有关.
结论:
- 环境化学物质,特别是四级化合物和有机酸盐阻燃剂,对寡头细胞的发展构成重大风险.
- 对于每个化学品类别,都确定了不同的毒性机制.
- 需要进一步研究这些化合物对人类神经发育的影响.
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