在帕金森病患者中,疲劳和MDS-UPDRS之间的关联:横截面研究
Marcelle Brandão Terra1, Josiane Lopes2, Maria Eduarda Brandão Bueno3
1Neurofunctional Physical Therapy Research Group (GPFIN), Graduate program in Rehabilitation Sciences - State University of Londrina, Londrina, Paraná, Brazil. marcelleterra@uel.br.
概括
帕金森病 (PD) 中的疲劳与非运动症状,焦虑和抑郁症密切相关,而不是单独的运动缺陷. 更高的BMI和更低的利沃多巴剂量也与PD患者疲劳增加有关.
科学领域:
- 神经学 神经学
- 运动障碍 运动障碍
- 生活质量研究 研究 生命质量研究
背景情况:
- 疲劳是帕金森病 (PD) 患者三分之一的主要致残症状.
- 了解导致疲劳的因素对于改善日常生活活动 (DLA) 至关重要.
研究的目的:
- 调查PD患者疲劳与非运动和运动症状之间的关联.
主要方法:
- 一项涉及100名PD患者的横截面研究.
- 收集的数据包括人口统计和临床信息 (例如,修改的Hoehn和Yahr尺度,焦虑,抑郁症).
- 运动障碍学会统一的帕金森病评级表 (MDS-UPDRS) 和帕金森疲劳表用于评估.
主要成果:
- "疲劳"组表现出更高的HY分数,非运动和运动DLA的严重程度更高,以及更多的运动并发症.
- 疲劳与更高的BMI,焦虑,抑郁和非运动症状的存在有关.
- 较低的日均列伏多巴剂量 (LEDD) 也与疲劳有关.
结论:
- 非运动症状是PD疲劳的更重要的决定因素,而不是运动症状.
- 疲劳与增加的BMI,焦虑,抑郁,较低的LEDD和更严重的DLAs非运动方面有关.
- 经历疲劳的患者往往会出现更高的HY分数,焦虑,抑郁,以及更糟糕的运动和非运动症状体验.
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