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Updated: Jun 29, 2025

Semi-automatic PD-L1 Characterization and Enumeration of Circulating Tumor Cells from Non-small Cell Lung Cancer Patients by Immunofluorescence

Semi-automatic PD-L1 Characterization and Enumeration of Circulating Tumor Cells from Non-small Cell Lung Cancer Patients by Immunofluorescence

Published on: August 14, 2019

在未知主部位的癌症中,PD-L1表达和微卫星不稳定性 (MSI)

João Neif Antonio Junior¹, Daniel D 'Almeida Preto^1,2, Maria Eduarda Zanatta Neder Lazarini²

¹Department of Clinical Oncology, Barretos Cancer Hospital, Barretos, Brazil.

International journal of clinical oncology

|March 26, 2024

概括

在未知原发性癌症 (CUP) 中,大约1/5的患者观察到PD-L1表达,并且与更好的生存率有关. 微卫星不稳定性 (MSI) 是罕见的,这表明CUP的免疫治疗反应有限.

科学领域:

在瘤学瘤学.
免疫治疗是一种免疫疗法.
癌症生物标志物癌症生物标志物

背景情况:

未知原发性癌症 (CUP) 由于其异质性质, presents一个诊断挑战.
瘤微环境因素可能会影响CUP的临床结果.
微卫星不稳定性 (MSI) 和PD-L1表达在CUP中的作用需要进一步研究.

研究的目的:

在CUP中评估PD-L1表达和MSI状态.
探索PD-L1,MSI和CUP中的临床病理特征之间的关联.
为了评估PD-L1和MSI在CUP患者的预后意义.

主要方法:

使用免疫组织化学 (组合阳性得分 - CPS) 评估PD-L1表达.
通过聚合酶链反应 (PCR) 确定MSI状态,使用六合复合标记面板.
分析了临床病理数据和整体存活率.

主要成果:

在研究的CUP队列中,MSI是一个罕见的事件 (1.6%).
在18.3%的病例中检测到PD-L1表达,并与非内脏和结节转移相关.
PD-L1表达与显著改善的整体存活率相关 (18.7 vs 3.0个月).

结论:

在CUP患者的一个子集中,PD-L1表达与改善的生存率有关.
在CUP中MSI不常见,可能会限制免疫疗法的疗效.
对CUP瘤微环境和免疫疗法的进一步研究是有必要的,以改善患者的治疗结果.

关键词:

免疫检查点蛋白质的免疫检查点蛋白质.免疫治疗是一种免疫疗法.微卫星的不稳定性是微观的新生体新生体新生体不知名的初级初级.

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