酒精使用障碍与整体感知相遇的地方:对结构和功能神经成像数据的元分析观点
Markus Muehlhan1,2, Carolin Spindler1, Sandra Nowaczynski1,2,3
1Department of Psychology, Faculty of Human Sciences, MSH Medical School Hamburg, Hamburg, Germany.
Journal of neurochemistry
|March 26, 2024
概括
酒精使用障碍 (AUD) 改变了大脑处理身体信号 (内接收) 的方式,特别是在突出和体运动网络中. 针对这些网络的干预措施可能有助于减少AUD并防止复发.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 成研究 研究成研究
背景情况:
- 酒精使用障碍 (AUD) 与改变的整体感受,身体内部信号的处理有关.
- 假设大脑的结构变化,特别是岛屿,会导致AUD中受体感受受损失.
- 有限的研究直接调查了与AUD相关的灰质减少和整感受缺陷之间的联系.
研究的目的:
- 为了比较对整体受理的分析结果与最近对AUD灰质减少的分析结果.
- 确定与整体感应相关的功能性大脑网络及其与AUD相关的结构变化重叠.
主要方法:
- 系统的文献搜索确定了25个整体受体研究.
- 激活概率估计 (ALE) 对于整感应结果的空间收.
- 连接分析以测试整体感应和AUD集群之间的重叠.
- 超分析连接建模 (MACM) 和静止状态功能连接以映射互感网络.
- 行为领域分析以表征重叠集群的功能配置文件.
主要成果:
- ALE在左侧中间岛屿中发现了一个整接收集群,与AUD灰色物质减少集群没有直接重叠.
- MACM和静止状态分析揭示了一个广泛的整感受网络,涉及insulae,thalami,基底核和皮质区域,与突出和体运动网络密切相关.
- 在八个AUD灰色物质减少集群中,有五个位于这些已识别的整感受网络内,与突出控制,体运动功能和皮肤感觉有关.
结论:
- 结果表明,AUD中整体感应信号的突出映射发生了变化,影响了动作控制和感官集成.
- 这些发现支持针对突出和体运动网络的干预措施,以解决AUD中的感觉缺陷.
- 潜在的干预措施包括正念,愉快的触摸和跨磁刺激,以减少AUD并防止复发.
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