患有先天性心脏病的婴儿心力衰竭和肠道炎症之间的关系
Qi-Liang Zhang1,2, Xiu-Hua Chen3,4, Si-Jia Zhou3,4
1Department of Cardiac Surgery, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China. zhangqiliang2020@163.com.
BMC microbiology
|March 26, 2024
概括
患有先天性心脏病 (CHD) 和心力衰竭 (HF) 的婴儿表现出改变的肠道细菌,其多样性较低,Enterococcus增加. 这可能会加剧肠道炎症和心力衰竭的进展.
科学领域:
- 儿童心脏病学 儿童心脏病学
- 胃肠病学 胃肠病学
- 微生物组研究 微生物组研究
背景情况:
- 先天性心脏病 (CHD) 经常与婴儿心力衰竭 (HF) 相关.
- 肠道微生物群在婴儿健康中的作用,特别是在CHD-HF等复杂疾病中,是一个新兴的研究领域.
研究的目的:
- 研究患有先天性心脏病 (CHD) 的婴儿心力衰竭 (HF) 和肠道炎症之间的关联.
- 分析肠道微生物组成及其与CHD-HF的婴儿的炎症标志物和心脏功能的相关性.
主要方法:
- 从20名患有HF和CHD的婴儿和20名年龄/性别匹配的对照人群收集了便样本.
- 酶相关免疫测试和16S rDNA测序被用于评估炎症因素和肠道微生物群.
主要成果:
- 患有HF和CHD的婴儿表现出明显增加的促炎细胞因子 (IL-1β,IL-4,IL-6,TNF-α) 和减少的IL-10.
- 在HF组中观察到肠道微生物多样性的减少和Enterococcus的更多,Bifidobacterium的减少.
- 微生物多样性和Enterococcus丰富度与炎症标志物相关,与IL-10水平负相关.
结论:
- 患有冠状动脉疾病相关的HF的婴儿存在肠道微生物群的疾病,其特点是减少多样性和不平衡,有利于像Enterococcus这样的致病细菌.
- 这种失生症和相关的肠道炎症可能会导致这些婴儿心力衰竭的恶化和进展.
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