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慢性缺氧重塑瘤微环境,以支持质瘤干细胞生长

J G Nicholson1, S Cirigliano1, R Singhania1

  • 1Department of Neurology, Weill Cornell Medicine, New York, NY, USA.

Acta neuropathologica communications
|March 26, 2024
PubMed
概括

长期与质瘤干细胞 (GSCs) 共培养的大脑器官显示慢性缺氧和氧化应激促进瘤生长. 星球细胞由缺血网络驱动,分泌加速GSC扩张的因素,这可能解释与年龄相关的质瘤攻击性.

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