潜在的眼睛指标来区分后皮层缩和典型的阿尔茨海默病:使用光学相干断层扫描血管造影的横截面研究
Yan Sun1, Lumi Zhang1, Hui Ye2
1Department of Neurology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People's Republic of China.
Alzheimer's research & therapy
|March 26, 2024
概括
后皮层缩 (PCA) 和阿尔茨海默病 (AD) 显示出类似的视网膜变化. 光学连贯断层扫描血管造影 (OCTA) 可能有助于非侵入性地检测这些痴呆症,尽管需要进一步的研究.
科学领域:
- 眼科医生 眼科 眼科
- 神经学 神经学
- 医疗成像医学成像
背景情况:
- 后皮层缩 (PCA) 是一种痴呆症,其特点是视觉功能障碍和保持认知,使早期诊断复杂化.
- 识别基底标记物可能有助于区分PCA与典型的阿尔茨海默病 (AD).
研究的目的:
- 在PCA患者中调查潜在的 fundus标记物.
- 将这些标志物与阿兹海默症患者的标志物进行比较,以确定诊断模式.
主要方法:
- 使用光学连贯断层扫描 (OCT) 和光学连贯断层扫描血管图 (OCTA) 进行视网膜成像.
- 对PCA,AD和健康对照 (HC) 组进行了神经心理评估和 fundus检查.
- 统计分析包括ANCOVA,通用线性模型,相关性和ROC曲线分析.
主要成果:
- 与HC相比,PCA患者表现出较薄的视网膜神经纤维和质细胞层.
- 与HC相比,PCA患者的表面和中间毛细管流域减少.
- 虽然MMSE最好地将AD/PCA与HC区分开来,但MoCA和OCTA参数的组合将PCA与AD区分开来.
结论:
- PCA和AD共享类似的基础结构和微血管损伤.
- OCTA显示出非侵入性检测PCA和AD的潜力,需要进一步调查.
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