豆衍生异黄作为化学预防剂,针对癌症预防和治疗的多种信号通路
Agnieszka Kaufman-Szymczyk1, Justyna Jalmuzna1, Katarzyna Lubecka-Gajewska1
1Department of Biomedical Chemistry, Faculty of Health Sciences, Medical University of Łódź, Łódź, Poland.
British journal of pharmacology
|March 26, 2024
概括
豆异黄在癌症中表现出双重作用,抑制癌症的生长,但有时会促进癌症的生长. 本综述详细介绍了它们复杂的分子机制,针对关键途径,并作为癌症预防和治疗的表观遗传调节器.
科学领域:
- 分子生物学分子生物学
- 在瘤学瘤学.
- 营养科学 营养科学
背景情况:
- 豆异黄具有化学预防和化学治疗两种特性.
- 异黄在癌症中表现出双重作用,抑制癌症的生长,同时也可能促进癌症的生长.
- 了解分子机制对于利用它们的治疗潜力至关重要.
研究的目的:
- 综合审查大豆衍生异黄在癌细胞中的分子机制.
- 阐明异黄是如何准多个细胞信号通路的.
- 讨论它们作为表观遗传调节剂和癌症干细胞抑制剂的作用.
主要方法:
- 关于分子机制的综合文献综述.
- 对HOTAIR/SMARCB1,VEGF/CXCL12/CXCR4和E2/ERα/NGB等信号通路的研究进行分析.
- 包括对表观遗传调制 (miRNAs) 和癌症干细胞抑制的研究.
主要成果:
- 大豆异黄调节关键癌症通路,包括HOTAIR/SMARCB1,VEGF/CXCL12/CXCR4和E2/ERα/NGB.
- 异黄作为表观遗传调节剂,影响像miR-155,miR-34a和miR-10a-5p这样的miRNA.
- 它们抑制了癌症干细胞和表皮细胞转化为介质细胞的转变,表明了治疗潜力.
结论:
- 大豆异黄在癌细胞内表现出复杂的分子相互作用.
- 它们调节各种信号通路和表观遗传因子的能力强调了它们的治疗前景.
- 进一步的研究和临床试验对于优化大豆异黄在癌症治疗和预防中的使用至关重要.
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