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富茶中不可提取的多醇通过控制结肠微生物向释放来缓解性结肠炎,以抑制小鼠的肠道炎症

Chengcheng Yang¹, Wuqi Yang¹, Yu Wang¹

¹Shaanxi Engineering Laboratory for Food Green Processing and Safety Control, and Shaanxi Key Laboratory for Hazard Factors Assessment in Processing and Storage of Agricultural Products, College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an 710119, China.

Journal of agricultural and food chemistry

|March 26, 2024

概括

不能提取的结合多 (NEPs) 准结肠,释放有益的化合物. 通过调节肠道微生物群和增加短链脂肪酸,NEPs有效地减轻性结肠炎的症状.

科学领域:

微生物学微生物学
营养科学营养科学
胃肠病学胃肠病学

背景情况:

性结肠炎 (UC) 是一种慢性炎症性肠病.
饮食中的多醇显示治疗潜力,但通常具有较差的生物可用性.
富茶中的非可提取多 (NEP) 是结合多的独特来源.

研究的目的:

为了研究从富茶中准释放NEP的结肠微生物群.
在UC的小鼠模型中识别NEP的抗炎机制.
评估与食纤维 (DFs) 相比,NEPs在缓解UC方面的有效性.

主要方法:

在C57BL/6J小鼠中诱导了硫酸 (DSS) 的UC.
小鼠被食食食食食食食食食食食食食食食食食食食食食食食食食食食食食食食食食食食食食食食食食食食食食 37天.
分析了肠道微生物组成,短链脂肪酸 (SCFA) 生产和结肠炎症.

主要成果:

NEPs在结肠中显著释放结合的p-基酸和奎尔丁.
补充NEP增加了结肠SCFA的产生,改变了肠道微生物群的组成 (增加了Dubosiella,Enterorhabdus;减少了Alistipes,Romboutsia).
在缓解UC症状和结肠炎症方面,NEP比DF更有效.

结论:

NEPs作为宏分子载体,可向结肠提供向的多.
尼普调节肠道微生物群和SCFA的产生,从而减少结肠炎症.
尼普在治疗性结肠炎方面具有显著的治疗潜力.

关键词:

的茶是什么意思我们的肠道微生物群.肠道炎症是一种肠道炎症.不能提取的多醇是不可提取的性结肠炎是一种

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