系统性红斑狼患者之间的流体认知
Laura C Plantinga1, Jinoos Yazdany1, Bradley D Pearce2
1University of California, San Francisco.
Arthritis care & research
|March 26, 2024
概括
流体认知,特别是注意力和抑制控制,在患有系统性红斑狼 (SLE) 的人群中经常受到损害. 更高的身体功能,表现和教育与较低的损伤风险有关.
科学领域:
- 神经科学是一个神经科学.
- 类风湿病学 类风湿病学
- 认知科学 认知科学
背景情况:
- 系统性红斑狼 (SLE) 是一种慢性自身免疫性疾病,可以影响多个器官系统,包括中枢神经系统.
- 认知功能障碍是SLE已知的但尚未完全理解的并发症,影响日常生活和疾病管理.
- 流动性认知,包括记忆,注意力和处理速度等能力,对于适应性功能至关重要.
研究的目的:
- 在被诊断为全身性红斑狼 (SLE) 的个体中描述流体认知及其相关因素.
- 为了确定SLE队列中潜在的流体认知障碍的人口和临床相关性.
主要方法:
- 在2019年10月至2022年5月期间,对199名SLE患者的队列进行了评估.
- 使用NIH工具箱流体认知电池评估流体认知,测量诸如记忆,注意力和处理速度等领域.
- 多变量逻辑回归分析了参与者特征与流体认知障碍 (定义为>1.5 SD低于平均值) 之间的关联.
主要成果:
- 与普通人群相比,参与者在流体认知 (87.2) 特别是注意力/抑制性控制 (82.0) 中的平均得分较低.
- 工作状态,更高的身体功能和身体表现与认知障碍的几率降低有关.
- 较低的教育程度与流体认知障碍的可能性增加相关.
结论:
- 患有SLE的个体表现出减少的流体认知,注意力和抑制控制特别受到影响.
- 就业状况,身体健康和教育水平是与SLE患者认知功能相关的重要因素.
- 需要进一步的研究和干预措施来支持SLE人口的认知健康.
更多相关视频
09:01Flow Cytometric Analysis of Lymphocyte Infiltration in Central Nervous System during Experimental Autoimmune Encephalomyelitis
Published on: November 17, 2020
7.1K
09:43Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
2.9K
相关概念视频
Autoimmune Disorders
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
Concept and Mechanism of Autoimmune Diseases
The immune system...
Nephrotic Syndrome I : Introduction
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
Nephrotic Syndrome II : Assessment and Medical Management
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document any history...
Nephrotic Syndrome III : Nursing Management
Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
Chronic Kidney Disease II: Clinical Manifestations
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
