在患有低梯度严重大动脉狭窄症的患者中,预测症状的发展和大动脉置换
Daisuke Miyahara1, Masaki Izumo1, Yukio Sato1
1Department of Cardiology, St Marianna University School of Medicine, 2-16-1, Sugao, Miyamae-ku, Kawasaki 216-8511, Japan.
European heart journal open
|March 26, 2024
概括
患有低梯度严重大动脉狭窄症的无症状患者的预后更差. 运动应力回声心脏图,特别是中腕心电图E/e.
科学领域:
- 心脏病学 心脏病学
- 心声回声扫描 (Echocardiography) 是一种心声回声扫描.
- 膜心脏疾病 膜心脏疾病
背景情况:
- 有限的证据存在于运动压力回声心电图 (ESE) 的预后价值在无症状患者低梯度严重的大动脉狭窄 (AS).
- 风险分层对于指导这种患者群体的管理至关重要.
研究的目的:
- 评估ESE在低梯度严重AS无症状患者的预后影响.
- 确定ESE在这个特定组的风险分层中的附加值.
主要方法:
- 对122名无症状患者进行了回顾性观察性研究,这些患者患有中度或低梯度的严重AS,并保留了射出分数.
- 患者接受了ESE,并随访AS相关事件.
- 多变量考克斯回归分析被用来识别事件的独立预测因素.
主要成果:
- 与中度AS患者相比,低梯度严重AS患者的无事件生存率明显较低.
- 运动期间的额头肌E/e'比率与AS相关事件独立相关,这些事件发生在低梯度严重AS患者中 (HR=1.075,P<0.001).
结论:
- 无症状的低梯度严重AS患者的预后比中度AS患者的预后更差.
- 运动期间的 mitra E/e' 比率是低梯度严重AS患者风险分层的一个有价值的参数.
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