患者报告的结果与纤维化间歇性肺病中的肺功能和死亡率的关联:前性队列研究
Jennifer D Duke1, Madison Roy2, Shannon Daley1
1Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, USA.
在纤维化间歇性肺病 (f-ILD) 中,患者报告的结果指标 (PROM) 与肺功能相关,并预测死亡率. 这些PROM可以增强临床评估和以患者为中心的研究成果.
科学领域:
- 肺部医学 肺部医学
- 临床研究 临床研究
- 患者报告的结果
背景情况:
- 纤维化间歇性肺病 (f-ILD) 显著影响患者的福祉.
- 患者报告的结果指标 (PROM) 提供了对疾病负担的直接洞察.
- 评估PROM与肺功能和死亡率的关联对于f-ILD管理至关重要.
研究的目的:
- 评估选择的PROM与f-ILD患者的基线和纵向肺功能之间的关联.
- 确定PROM是否可以预测f-ILD的全因死亡率.
- 探索PROMs与随时间变化的肺功能之间的关系.
主要方法:
- 一项前性,单中心研究,涉及199名成年f-ILD患者超过3年.
- 使用医学研究理事会修改的呼吸障碍量表 (mMRC),慢性呼吸道问卷 (CRQ) 和自我管理能力量表 (SMAS-30).
- 根据基线临床发现评估PROM,强迫生命能力 (FVC%) 和肺部对一氧化碳的扩散能力 (DLCO%) 的变化,以及死亡率.
主要成果:
- 较低的mMRC,更高的CRQ (物理/情绪) 和更高的SMAS-30分数与更好的基线FVC%相关.
- 在mMRC,CRQ和SMAS-30的短期变化与FVC%和DLCO%的变化有关.
- 基线和序列PROM变化独立预测f-ILD患者的死亡率.
结论:
- PROMs是评估f-ILD疾病影响的有价值工具.
- PROM评估与肺功能相关,并预测死亡率.
- 整合PROM可以增强临床实践和以患者为中心的f-ILD研究.
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