相关实验视频
Updated: Jun 29, 2025

13:28
Methodology for Sputum Induction and Laboratory Processing
Published on: December 17, 2017
27.6K
慢性肺炎:在频繁和不频繁的恶化因素中的系统性蛋白质组概况
Cesar Jessé Enríquez-Rodríguez1,2,3, Carme Casadevall1,2,3, Rosa Faner2,4
1Servei de Pneumologia, Hospital del Mar - IMIM, MELIS Dept, Universitat Pompeu Fabra and BRN, Barcelona, Spain.
ERJ open research
|March 26, 2024
概括
慢性阻塞性肺病 (COPD) 频繁恶化 (FE) 的患者表现出明显的血蛋白质组概况. 这些特征涉及免疫失调,部分与急性恶化 (AE) 期间的特征重叠.
科学领域:
- 蛋白质组学是指蛋白质组学.
- 免疫学 免疫学 免疫学
- 呼吸系统医学 呼吸系统医学
背景情况:
- 慢性阻塞性肺病 (COPD) 患者可能会经历频繁的恶化 (FE),影响他们的健康结果.
- 对于FE和非频繁恶化剂 (NFE) 之间的系统性蛋白质组差异还不太清楚.
- 了解这些蛋白质组概况对于有针对性的治疗策略至关重要.
研究的目的:
- 调查和对比COPD患者的系统性蛋白质组形状,以FE与NFE相比.
- 在健康对照组 (HC) 和COPD急性恶化 (AE) 期间建立参考蛋白质组概况.
主要方法:
- 从稳定的COPD患者 (20 FE,20 NFE),HC (20) 和AE期间 (10) 的血样本分析.
- 使用无标签的液体染色学-协同质谱学和多重免疫试验进行蛋白质组分析.
- 采用基因本体学,通路丰富和网络分析来识别差异丰富的蛋白质/ (DAP) 和相关的分子通路.
主要成果:
- 与HC相比,在FE中确定了40个DAP,在NFE中10个DAP,在AE中63个DAP.
- 在COPD FE和AE期间显示出先天性和抗体介导免疫的失调.
- 特别是在AE期间观察到补充和凝血级联的变化.
结论:
- 特定的血蛋白质组概况与COPD患者的FE有关.
- 这些FE相关的蛋白质组发现与AE期间的配置文件有一些相似之处.
- 在实际的AE事件中存在独特的蛋白质基因变化,与稳定的FE配置文件不同.
更多相关视频
相关概念视频
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
2.5K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
Medical History
2.5K
Chronic Obstructive Pulmonary Disease-II: Pathophysiology
2.8K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
2.8K
Chronic Obstructive Pulmonary Disease
1.2K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
1.2K
Proteomics
7.3K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
7.3K
COPD: Pathogenesis and Clinical Features
269
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
269
COPD: Management Using Bronchodilators and Corticosteroids
202
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
202

