杆菌,持久性感染负担和结构性脑成像标志物
May A Beydoun1, Hind A Beydoun2, Yi-Han Hu1
1Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIA/NIH/IRP, Baltimore, MD 21224, USA.
Brain communications
|March 26, 2024
概括
持续性感染,包括Helicobacter pylori,与神经退行性疾病有关. 这项研究发现,H. pylori抗原水平,而不仅仅是血清阳性,与白质完整性和大脑体积相关,这表明针对性干预可以预防痴呆症.
科学领域:
- 神经科学是一个神经科学.
- 传染性疾病 传染性疾病
- 医疗成像医学成像
背景情况:
- 持续性感染,包括Helicobacter pylori (H. pylori),越来越多地与诸如痴呆症等非传染性疾病有关.
- 了解慢性感染和神经退行症之间的联系对于制定预防策略至关重要.
研究的目的:
- 调查H. pylori血清阳性,特定的H. pylori抗原水平和整体持久性感染负担与大脑结构和白质完整性之间的关联.
- 探索与阿尔茨海默病多基因风险相关的这些关联.
主要方法:
- 对635位认知正常的英国生物库参与者 (年龄40-70岁) 的横截面研究.
- 评估了H. pylori的血清阳性,五种H. pylori抗原的血清强度,以及总持续感染负担.
- 利用结构性MRI和扩散权重MRI测量大脑体积和白质完整性.
- 采用多变量调整的线性回归,按阿尔茨海默病多基因风险得分分层分.
主要成果:
- 很少有证据表明H. pylori血清阳性或感染负担与体积大脑结果之间存在关联.
- H. pylori抗原的血清强度 (真空化细胞毒素A,GroEL,外膜蛋白) 与通道特异性的白质完整性较差有关.
- 特定抗原与白质完整性和下皮质体积的相关性因阿尔茨海默氏症多基因风险水平而异.
结论:
- 特别是针对特定抗原的H. pylori抗原水平与白质完整性和大脑体积有关,独立于整体的H. pylori血清阳性.
- 研究结果强调了特定传染病原体及其成分在神经退行过程中的潜在作用.
- 结果可能有助于制定针对性干预措施,以预防痴呆症和其他神经退行性疾病.
相关概念视频
01:28Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
116
Peptic ulcer disease (PUD) presents with diverse symptoms depending on the location and severity of the ulcer. Clinical manifestations of peptic ulcer include dull pain and a burning sensation in the mid-epigastric region.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
116
01:16Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy
390
Helicobacter pylori, a resilient gram-negative bacterium, can thrive in the stomach's harsh, acidic environment. Infection with H. pylori leads to a cascade of events within the stomach lining. One of the critical disruptions caused by this bacterium is the interference with somatostatin production, a hormone responsible for regulating acid secretion. This interference tips the balance, escalating acid secretion and diminishing bicarbonate levels. This imbalance compromises the defensive...
390
01:30Peptic Ulcer Disease I: Introduction
168
Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
168