局部多尔佐胺作为辅助治疗与双边糖尿病黄斑胀的室内贝瓦西祖马布在双边糖尿病黄斑胀
Ata Sadr1, Meisam Sargazi1, Shahram Banaie1
1Ophthalmology, Zahedan University of Medical Sciences, Zahedan, IRN.
Cureus
|March 26, 2024
概括
在接受抗VEGF注射的糖尿病黄斑患者中,局部多佐胺可能会改善中央黄斑厚度,但不会提高视力敏度. 这项研究比较了多佐胺加贝瓦西祖马布与单独的贝瓦西祖马布用于糖尿病黄斑.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 内抗血管内皮生长因子 (VEGF) 药物是中心涉及糖尿病黄斑胀 (CI-DME) 的标准药物.
- 局部多尔佐胺可能会增加CI-DME的抗VEGF治疗.
- 这项研究调查了局部多佐胺与静脉内贝瓦齐祖马布 (IVB) 相结合的IVB单疗法.
研究的目的:
- 为了比较局部多佐胺加IVB和单独IVB在双边DME患者的疗效.
- 评估辅助局部多佐胺对视觉敏度和黄斑厚度的影响.
主要方法:
- 对25名双边DME患者 (50只眼睛) 进行前性随机对侧眼研究.
- 每月三次IVB注射给所有眼睛.
- 干预组接受了多佐胺滴剂;对照组接受了人工眼.
- 评估最佳校正视敏度 (BCVA),中央黄斑厚度 (CMT) 和眼内压力 (IOP) 每月一次,持续三个月.
主要成果:
- 在任何一组中,BCVA都没有显著改善.
- 这两组均显示CMT的下降.
- 辅助多尔佐胺在第3个月导致CMT显著减少,与安慰剂相比.
- 只有在多佐胺组中观察到IOP显著下降.
结论:
- 辅助局部多佐胺对IVB治疗的DME患者的CMT减少有好处.
- 与IVB单独治疗相比,局部多佐胺对BCVA改善没有添加作用.
- 进一步的研究可能会探索多佐胺在DME管理中的作用.
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