在中风患者中出现症状性静脉血栓栓塞的发生率
Mostafa Al Turk1, Michael Abraham1,2
1Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA.
Journal of intensive care medicine
|March 26, 2024
概括
埃诺沙巴林在预防中风患者的静脉血栓栓塞方面表现出与未分离的肝素相似的有效性. 埃诺沙巴林还显示出潜在的更安全的特征,观察到的内出血明显减少.
科学领域:
- 关键护理医学 关键护理医学
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
背景情况:
- 静脉血栓栓塞 (VTE) 是重症患者的常见并发症,特别是急性缺血性中风患者.
- 未分离的氨酸 (UFH) 和氨酸 (enoxaparin) 用于静脉瘤预防,但对中风患者的比较有效性和安全性仍有争议.
研究的目的:
- 为了比较VTE (深静脉血栓和肺栓塞) 的发生率和UFH与埃诺沙巴林在急性缺血性中风患者的VTE预防中的安全概况.
- 根据位置和症状分析静脉瘤亚分类,并评估内出血的风险.
主要方法:
- 对909名急性缺血性中风患者入院的神经急症监护室的患者进行了回顾性研究.
- 分析了634名患者,170名患者接受了埃诺沙巴林,464名患者接受了UFH用于静脉瘤预防.
- 记录了VTE事件和内出血,并在两组之间进行了比较.
主要成果:
- 在UFH组中,VTE发生率为4.1%,而在埃诺沙巴林组中为1.8% (不具有统计学意义).
- 肺栓塞发生在UFH患者的1.9%,而埃诺沙巴林组没有.
- 内出血发生在3.9%的UFH患者中,而埃诺沙巴林组为0% (统计学上显著).
结论:
- 在急性缺血性中风患者的VTE预防中,埃诺沙巴林与UFH同样有效.
- 埃诺沙巴林似乎是一种潜在的UFH更安全的替代品,与大脑内出血的风险明显降低有关.
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