之前的肺结核与发生的COPD的关联:一个前性队列研究
Zhilin Zeng1, Huilong Chen2, Zhonghe Shao3
1Department and Institute of Infectious Diseases, Tongji Hospital, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Huazhong University of Science and Technology, Wuhan, China.
Therapeutic advances in respiratory disease
|March 26, 2024
概括
以前患有肺结核 (PTB) 的病史显著增加患慢性阻塞性肺病 (COPD) 的风险. 这一发现强调了PTB作为COPD的关键独立风险因素,特别是在高负担地区.
科学领域:
- 肺部医学 肺部医学
- 流行病学 流行病学
- 呼吸系统健康 呼吸系统健康
背景情况:
- 预先肺结核 (PTB) 被怀疑有助于慢性阻塞性肺病 (COPD) 的发展.
- 之前的PTB对事件COPD风险的特定影响尚未在大型欧洲潜在队列中得到广泛研究.
研究的目的:
- 调查以前的PTB病史与患上COPD的风险之间的关联.
- 确定可能面临更高风险的特定子组.
主要方法:
- 采用了前性队列研究设计.
- 多变量考克斯比例模型用于计算危险比率 (HR) 和95%置信区间 (CI).
- 根据各种人口统计和生活方式因素进行了子组分析,包括年龄,性别,BMI,吸烟,饮酒,体力活动和多基因风险评分 (PRS).
主要成果:
- 该研究包括216,130名参与者,平均随访时间为12.6年,确定了2788起COPD病例.
- 具有先前PTB病史的个体表现出发生COPD的风险增加了87% (aHR = 1.87;95% CI: 1.26-2.77;p = 0.002).
- 在多个子组中观察到高风险,包括老年人群,男性,肥胖者,前吸烟者,目前饮酒者,体力活动较低的人以及低PRS和高PRS的人.
结论:
- 患有PTB的病史被确定为COPD的重要和独立风险因素.
- 医疗保健提供者应将先前的PTB视为COPD的关键风险因素,特别是在结核病流行率高的地区.
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