[慢性脑缺血患者轻度认知障碍的神经代谢疗法]
E A Antipenko1, A V Shulyndin2, K M Belyakov3
1Privolzhsky Research Medical University, N. Novgorod, Russia.
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
|March 26, 2024
概括
这项研究表明,使用Mexidol和Mexidol FORTE 250的连续治疗显著改善了慢性脑缺血患者的认知功能,并减少了慢性脑缺血患者的喘息. 该疗法还对神经元活动产生了积极影响,这表明它具有神经保护作用.
科学领域:
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
背景情况:
- 慢性脑缺血往往导致中度认知障碍.
- 认知缺陷显著影响患者的生活质量.
研究的目的:
- 为了评估一个涉及Mexidol和Mexidol FORTE 250的顺序治疗方案的疗效.
- 评估这种疗法对慢性脑缺血和认知障碍患者上层皮质功能的影响.
主要方法:
- 一项比较前性研究,涉及63名患有慢性脑缺血和中度认知障碍的患者.
- 患者接受了基本治疗加上连续的Mexidol/Mexidol FORTE 250或单独的基本治疗.
- 认知状态,喘息,焦虑,抑郁和神经活动被评估,使用各种尺度和跨磁刺激.
主要成果:
- 梅西多尔/梅西多尔FORTE 250组在认知功能 (MoCA,前额功能障碍电池,记忆测试) 中显示出显著的改善.
- 这个小组还经历了减轻的喘息,焦虑和抑郁症,改善了整体幸福感.
- 经磁刺激显示,中枢运动导电时间减少,与前额叶功能改善相关.
结论:
- 用Mexidol和Mexidol FORTE 250进行顺序治疗对患有慢性脑缺血和轻度认知障碍的患者来说是临床有效和安全的.
- 这种疗法在预防认知障碍的进展方面表现有前途.
- 治疗对神经元活动产生积极影响,支持其治疗效益.
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